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General Health Scientific References

Fertility | Women's Health | Urology | Rheumatology | General Health


LATEST RESEARCH UPDATE: A recent meta-analysis published in the Journal of the American Heart Association found that coenzyme Q10 (CoQ10) supplementation ameliorated statin associated muscle symptoms (SAMs) such as muscle pain, muscle weakness, muscle cramps, and muscle tiredness.This meta-analysis included 12 randomized controlled trials of intervention ranging from 1-3 months, with a total of 575 participants. Compared to placebo, CoQ10 ameliorated muscle pain, muscle weakness, muscle cramps, and muscle tiredness. The authors concluded that CoQ10 supplementation may be a complementary approach to statin-induced myopathy. For more information check out the full study.


Bone Health

Combination of Calcium and Vitamin D
Vitamin D
Vitamin K

(2012/01) Effect of vitamin K on bone mineral density: a meta-analysis of randomized controlled trials.

(2011/11) Intake of vitamin K1 and K2 and risk of hip fractures: The Hordaland Health Study.

(2011/06) Dietary vitamin K intake is associated with bone quantitative ultrasound measurements but not with bone peripheral biochemical markers in elderly men and women.

(2011/06) Vitamin K: fracture prevention and beyond.

(2009/06) Vitamin K treatment reduces undercarboxylated osteocalcin but does not alter bone turnover, density, or geometry in healthy postmenopausal North American women.

(2008/10) Vitamin K supplementation in postmenopausal women with osteopenia (ECKO trial): a randomized controlled trial.

(2008/05) Vitamin K1 intake is associated with higher bone mineral density and reduced bone resorption in early postmenopausal Scottish women: no evidence of gene-nutrient interaction with apolipoprotein E polymorphisms.

(2008/04) Effect of vitamin K supplementation on bone loss in elderly men and women.

(2007/04) Two-year randomized controlled trial of vitamin K1 (phylloquinone) and vitamin D3 plus calcium on the bone health of older women.

(2006/06) Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials.

(2003/07) Vitamin K1 supplementation retards bone loss in postmenopausal women between 50 and 60 years of age.

(2000/05) Dietary vitamin K intakes are associated with hip fracture but not with bone mineral density in elderly men and women.


Heart Health

Coenzyme Q10

(2018/09) Effects of Coenzyme Q10 on Statin‐Induced Myopathy: An Updated Meta‐Analysis of Randomized Controlled Trials.

(2012/12) A randomized, double-blind, placebo-controlled crossover study of coenzyme Q10 therapy in hypertensive patients with the metabolic syndrome.

(2012/11) Impact of coenzyme Q-10 on parameters of cardiorespiratory fitness and muscle performance in older athletes taking statins

(2012/11) The effect of coenzyme Q10 in statin myopathy.

(2012/08) Effect of coenzyme Q10 supplementation on statin-induced myalgias

(2012/02) Strategies to preserve the use of statins in patients with previous muscular adverse effects

(2010/07) Coenzyme Q10: a therapy for hypertension and statin-induced myalgia?

(2009/10) Blood pressure lowering efficacy of coenzyme Q10 for primary hypertension.

(2007/06) The role of coenzyme Q10 in statin-associated myopathy: a systematic review.

(2007/05) Effect of coenzyme q10 on myopathic symptoms in patients treated with statins

(2005/11) Muscle coenzyme Q10 level in statin-related myopathy.

(2004/05) Coenzyme Q10 in patients with end-stage heart failure awaiting cardiac transplantation: a randomized, placebo-controlled study.

(2003/01) Systematic review of effect of coenzyme Q10 in physical exercise, hypertension and heart failure.

(1999/05) Lack of effect of coenzyme Q on left ventricular function in patients with congestive heart failure.

(1999/03) Effect of hydrosoluble coenzyme Q10 on blood pressures and insulin resistance in hypertensive patients with coronary artery disease.

(1995/03) Coenzyme Q10 as an adjunctive in the treatment of chronic congestive heart failure. The Q10 Study Group.

(1994/12) Coenzyme Q10 in essential hypertension.

(1994/12) Treatment of essential hypertension with coenzyme Q10.

(1994/12) Italian multicenter study on the safety and efficacy of coenzyme Q10 as adjunctive therapy in heart failure. CoQ10 Drug Surveillance Investigators.

(1993/12) Effect of coenzyme Q10 therapy in patients with congestive heart failure: a long-term multicenter randomized study.

Omega-3 Fish Oil
Vitamin D


Immune Function

Vitamin D


Joint Health

Glucosamine and Chondroitin
Vitamin D


Sleep Health






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