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Fertility Scientific References

Fertility | Women's Health | Urology | Rheumatology | General Health


LATEST RESEARCH UPDATE: A recent secondary analysis of a prospective cohort from the Effects of Aspirin in Gestation and Reproduction assessed associations between preconception 25(OH)D levels and fecundability, pregnancy loss, and live birth rates among women age 18-40 years, with one to two previous pregnancy losses, trying to conceive. The frequency of hCG-detected pregnancies, clinical pregnancies, and live births was significantly higher among women with sufficient preconception 25(OH)D levels. This study highlights the potential protective role of vitamin D in promoting fertility and pregnancy. For more information, check out the full abstract here.


Female Fertility

Coenzyme Q10

(2017/05) The effect of dehydroepiandrosterone supplementation on ovarian response is associated with androgen receptor in diminished ovarian reserve women.

(2016/07) Effect of dehydroepiandrosterone administration in Chinese women over 37 years undergoing assisted reproductive techniques.

(2016/05) The effect of dehydroepiandrosterone (DHEA) supplementation on women with diminished ovarian reserve (DOR) in IVF cycle: Evidence from a meta-analysis.

(2015/12) A meta-analysis of dehydroepiandrosterone supplementation among women with diminished ovarian reserve undergoing in vitro fertilization or intracytoplasmic sperm injection.

(2015/03) Dehydroepiandrosterone decreases the age-related decline of the in vitro fertilization outcome in women younger than 40 years old.

(2015/02) Potential benefit of dehydroepiandrosterone supplementation for infertile but not poor responder patients in a IVF program.

(2014/07) A randomized, controlled, pilot trial on the effect of dehydroepiandrosterone on ovarian response markers, ovarian response, and in vitro fertilization outcomes in poor responders.

(2014/06) Effect of dehydroepiandrosterone administration in patients with poor ovarian response according to the Bologna criteria.

(2014/06) Role of dehydroepiandrosterone in improving oocyte and embryo quality in IVF cycles.

(2014/02) Does dehydroepiandrosterone supplementation really affect IVF-ICSI outcome in women with poor ovarian reserve?

(2014/01) DHEA pre-treated patients, poor responders to a first IVF (ICSI) cycle: clinical results.

(2013/11) A prospective study on role of dehydroepiandrosterone (DHEA) on improving the ovarian reserve markers in infertile patients with poor ovarian reserve.

(2013/10) DHEA supplementation positively affects spontaneous pregnancies in women with diminished ovarian function.

(2013/07) Dehydroepiandrosterone supplementation improves predictive markers for diminished ovarian reserve: serum AMH, inhibin B and antral follicle count.

(2013/05) DHEA supplementation may improve IVF outcome in poor responders: a proposed mechanism.

(2013/01) Starting and resulting testosterone levels after androgen supplementation determine at all ages in vitro fertilization(IVF) pregnancy rates in women with diminished ovarian reserve (DOR).

(2012/09) DHEA supplementation improves follicular microenviroment in poor responder patients.

(2010/10) Addition of dehydroepiandrosterone (DHEA) for poor-responder patients before and during IVF treatment improves the pregnancy rate: a randomized prospective study.

(2010/11) Dehydroepiandrosterone (DHEA) reduces embryo aneuploidy: direct evidence from preimplantation genetic screening (PGS).

(2010/10) Addition of dehydroepiandrosterone (DHEA) for poor-responder patients before and during IVF treatment improves the pregnancy rate: a randomized prospective study.

Folate/Folic Acid

(2017/12) Inositol supplement improves clinical pregnancy rate in infertile women undergoing ovulation induction for ICSI or IVF-ET.

(10/2016) Inositol Treatment and ART Outcomes in Women with PCOS.

(08/2016) Prospective Randomized Study on the Influence of Myoinositol in PCOS Women Undergoing IVF in the Improvement of Oocyte Quality, Fertilization Rate, and Embryo Quality

(08/2015) Inositol versus Metformin administration in polycystic ovary syndrome patients: a case–control study

(06/2015) Myo-inositol therapy for poor-responders during IVF: a prospective controlled observational trial

(02/2015) Ovulation induction with myo-inositol alone and in combination with clomiphene citrate in polycystic ovarian syndrome patients with insulin resistance

(12/2013) The combined therapy myo-inositol plus D-chiro-inositol, rather than D-chiro-inositol, is able to improve IVF outcomes: results from a randomized controlled trial

(04/2013) Endocrine and clinical effects of myo-inositol administration in polycystic ovary syndrome. A randomized study.

(07/2012) Pretreatment with myo-inositol in non polycystic ovary syndrome patients undergoing multiple follicular stimulation for IVF: a pilot study.

(05/2011) Effects of myo-inositol supplementation on oocyte's quality in PCOS patients: a double-blind trial.

(04/2011) Myo-inositol rather than D-chiro-inositol is able to improve oocyte quality in intracytoplasmic sperm injection cycles. A prospective, controlled, randomized trial.

(04/2010) Insulin sensitiser agents alone and in co-treatment with r-FSH for ovulation induction in PCOS women.

(05/2009) Myo-inositol may improve oocyte quality in intracytoplasmic sperm injection cycles. A prospective, controlled, randomized trial.

(09/2007) Randomized, double blind placebo-controlled trial: effects of myo-inositol on ovarian function and metabolic factors in women with PCOS.


(2017/12) The impact of melatonin on the sleep patterns of women undergoing IVF: a double blind RCT.

(2017/04) Melatonin levels in follicular fluid as markers for IVF outcomes and predicting ovarian reserve.

(2016/01) Effect of myo-inositol and melatonin versus myo-inositol, in a randomized controlled trial, for improving in vitro fertilization of patients with polycystic ovarian syndrome.

(2014/10) Melatonin: shedding light on infertility? - a review of the recent literature.

(2014/05) Oral melatonin supplementation improves oocyte and embryo quality in women undergoing in vitro fertilization-embryo transfer.

(2014/01) Melatonin supplementation during controlled ovarian stimulation for women undergoing assisted reproductive technology: systematic review and meta-analysis of randomized controlled trials.

(2012/02) The efficacy of melatonin administration on oocyte quality.

(2011/11) Effect of a supplementation with myo-inositol plus melatonin on oocyte quality in women who failed to conceive in previous in vitro fertilization cycles for poor oocyte quality: a prospective, longitudinal, cohort study.

(2011/09) Melatonin improves the oocyte and the embryo in IVF patients with sleep disturbances, but does not improve the sleeping problems.

(2010/06) Effect of the treatment with myo-inositol plus folic acid plus melatonin in comparison with a treatment with myo-inositol plus folic acid on oocyte quality and pregnancy outcome in IVF cycles. A prospective, clinical trial.

(2008/04) Oxidative stress impairs oocyte quality and melatonin protects oocytes from free radical damage and improves fertilization rate.

Omega-3 Fatty Acids
Vitamin D


Male Fertility

Coenzyme Q10
Folate/Folic Acid
Omega-3 Fatty Acids
Vitamin C
Vitamin D
Vitamin E






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