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General Health Scientific References

Fertility | Women's Health | Urology | Rheumatology | General Health


LATEST RESEARCH UPDATE: A meta-analysis of 13 trials concluded that omega‐3 fish oil supplementation resulted in a statistically significant reductions in risk of myocardial infarction, total coronary heart disease (CHD) and CHD death, and total cardiovascular disease (CVD) and CVD death. This analysis updated previous meta‐analyses by adding 3 recent large randomized controlled clinical trials, increasing the sample size by 64%. While omega-3 doses varied, most included trials had a dose around 850 mg/day.This evidence suggests that omega‐3 fish oil supplementation is associated with lower risk of MI, total CHD, total CVD, and death from CHD or CVD causes. For more information check out the full study.


Bone Health

Combination of Calcium and Vitamin D
Vitamin D
Vitamin K

(2012/01) Effect of vitamin K on bone mineral density: a meta-analysis of randomized controlled trials.

(2011/11) Intake of vitamin K1 and K2 and risk of hip fractures: The Hordaland Health Study.

(2011/06) Dietary vitamin K intake is associated with bone quantitative ultrasound measurements but not with bone peripheral biochemical markers in elderly men and women.

(2011/06) Vitamin K: fracture prevention and beyond.

(2009/06) Vitamin K treatment reduces undercarboxylated osteocalcin but does not alter bone turnover, density, or geometry in healthy postmenopausal North American women.

(2008/10) Vitamin K supplementation in postmenopausal women with osteopenia (ECKO trial): a randomized controlled trial.

(2008/05) Vitamin K1 intake is associated with higher bone mineral density and reduced bone resorption in early postmenopausal Scottish women: no evidence of gene-nutrient interaction with apolipoprotein E polymorphisms.

(2008/04) Effect of vitamin K supplementation on bone loss in elderly men and women.

(2007/04) Two-year randomized controlled trial of vitamin K1 (phylloquinone) and vitamin D3 plus calcium on the bone health of older women.

(2006/06) Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials.

(2003/07) Vitamin K1 supplementation retards bone loss in postmenopausal women between 50 and 60 years of age.

(2000/05) Dietary vitamin K intakes are associated with hip fracture but not with bone mineral density in elderly men and women.


Heart Health

Coenzyme Q10

(2019/02) Effect of coenzyme Q10 in Europeans with chronic heart failure: A sub-group analysis of the Q-SYMBIO randomized double-blind trial.

(2018/09) Effects of Coenzyme Q10 on Statin‐Induced Myopathy: An Updated Meta‐Analysis of Randomized Controlled Trials.

(2012/12) A randomized, double-blind, placebo-controlled crossover study of coenzyme Q10 therapy in hypertensive patients with the metabolic syndrome.

(2012/11) Impact of coenzyme Q-10 on parameters of cardiorespiratory fitness and muscle performance in older athletes taking statins

(2012/11) The effect of coenzyme Q10 in statin myopathy.

(2012/08) Effect of coenzyme Q10 supplementation on statin-induced myalgias

(2012/02) Strategies to preserve the use of statins in patients with previous muscular adverse effects

(2010/07) Coenzyme Q10: a therapy for hypertension and statin-induced myalgia?

(2009/10) Blood pressure lowering efficacy of coenzyme Q10 for primary hypertension.

(2007/06) The role of coenzyme Q10 in statin-associated myopathy: a systematic review.

(2007/05) Effect of coenzyme q10 on myopathic symptoms in patients treated with statins

(2005/11) Muscle coenzyme Q10 level in statin-related myopathy.

(2004/05) Coenzyme Q10 in patients with end-stage heart failure awaiting cardiac transplantation: a randomized, placebo-controlled study.

(2003/01) Systematic review of effect of coenzyme Q10 in physical exercise, hypertension and heart failure.

(1999/05) Lack of effect of coenzyme Q on left ventricular function in patients with congestive heart failure.

(1999/03) Effect of hydrosoluble coenzyme Q10 on blood pressures and insulin resistance in hypertensive patients with coronary artery disease.

(1995/03) Coenzyme Q10 as an adjunctive in the treatment of chronic congestive heart failure. The Q10 Study Group.

(1994/12) Coenzyme Q10 in essential hypertension.

(1994/12) Treatment of essential hypertension with coenzyme Q10.

(1994/12) Italian multicenter study on the safety and efficacy of coenzyme Q10 as adjunctive therapy in heart failure. CoQ10 Drug Surveillance Investigators.

(1993/12) Effect of coenzyme Q10 therapy in patients with congestive heart failure: a long-term multicenter randomized study.

Omega-3 Fish Oil

(2019/09) Marine Omega‐3 Supplementation and Cardiovascular Disease: An Updated Meta‐Analysis of 13 Randomized Controlled Trials Involving 127 477 Participants.

(2014/07) Long-Chain Omega-3 Fatty Acids Eicosapentaenoic Acid and Docosahexaenoic Acid and Blood Pressure: A Meta-Analysis of Randomized Controlled Trials.

(2011/11) Omega-3 fatty acids and cardiovascular disease: effects on risk factors, molecular pathways, and clinical events.

(2011/10) Impact of low vs. moderate intakes of long-chain n-3 fatty acids on risk of coronary heart disease.

(2010/03) Long-chain omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid dose-dependently reduce fasting serum triglycerides

(2010/01) Fish oil for primary and secondary prevention of coronary heart disease.

(2008/07) Reduction in the recurrence of stroke by eicosapentaenoic acid for hypercholesterolemic patients: subanalysis of the JELIS trial.

(2006/12) The triglyceride-lowering effects of a modest dose of docosahexaenoic acid alone versus in combination with low dose eicosapentaenoic acid in patients with coronary artery disease and elevated triglycerides.

(2006/08) Antiatherosclerotic and antithrombotic effects of omega-3 fatty acids.

(2006/08) Secondary prevention of coronary artery disease with omega-3 fatty acids.

(2006/08) Combination Therapy with Statins and Omega-3 Fatty Acids

(2006/08) Dietary omega-3 fatty acid intake and cardiovascular risk.

(2006/03) The independent effects of eicosapentaenoic acid and docosahexaenoic acid on cardiovascular risk factors in humans.

(2002/11) Fish Consumption, Fish Oil, Omega-3 Fatty Acids, and Cardiovascular Disease

(1999/08) Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial.

Vitamin D


Immune Function

Vitamin D


Joint Health

Glucosamine and Chondroitin
Palmitate Monoethanolamide (PEA)
Vitamin D


Mental Health

Omega-3 Fish Oil
Palmitate Monoethanolamide (PEA)
Vitamin D


Sleep Health






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