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Fertility Scientific References

Fertility | Women's Health | Urology | Rheumatology | General Health


LATEST RESEARCH UPDATE: A recent systematic review and meta-analysis of eight randomized controlled trials (RCTs) summarized the effects of myoinositol (MI) supplementation on controlled ovarian hyperstimulation (COH) variables (gonadotropin use, duration of stimulation, and number of canceled cycles) in both patients with and without PCOS, undergoing IVF.The analysis of six studies comparing MI to control found a significant reduction in length of COH and gonadotropin dose, without differences in canceled cycle rate, number of total and mature oocytes per cycle, and clinical pregnancy rate per cycle. In summary, inositol reduced the amount of gonadotropins used in both PCOS and non-PCOS women and reduced COH length in women with PCOS. For more information, check out the full abstract here.


Female Fertility

Coenzyme Q10

(2018/11) DHEA use to improve likelihood of IVF/ICSI success in patients with diminished ovarian reserve: A systematic review and meta-analysis.

(2018/09) Dehydroepiandrosterone (DHEA) supplementation improves in vitro fertilization outcomes of poor ovarian responders, especially in women with low serum concentration of DHEA-S: a retrospective cohort study.

(2017/12) Dehydroepiandrosterone as a potential agent to slow down ovarian aging.

(2017/05) The effect of dehydroepiandrosterone supplementation on ovarian response is associated with androgen receptor in diminished ovarian reserve women.

(2017/04) Evaluation of Dehydroepiandrosterone Supplementation on Diminished Ovarian Reserve: A Randomized, Double-Blinded, Placebo-Controlled Study.

(2016/07) Effect of dehydroepiandrosterone administration in Chinese women over 37 years undergoing assisted reproductive techniques.

(2016/05) The effect of dehydroepiandrosterone (DHEA) supplementation on women with diminished ovarian reserve (DOR) in IVF cycle: Evidence from a meta-analysis.

(2015/12) A meta-analysis of dehydroepiandrosterone supplementation among women with diminished ovarian reserve undergoing in vitro fertilization or intracytoplasmic sperm injection.

(2015/03) Dehydroepiandrosterone decreases the age-related decline of the in vitro fertilization outcome in women younger than 40 years old.

(2015/02) Potential benefit of dehydroepiandrosterone supplementation for infertile but not poor responder patients in a IVF program.

(2014/07) A randomized, controlled, pilot trial on the effect of dehydroepiandrosterone on ovarian response markers, ovarian response, and in vitro fertilization outcomes in poor responders.

(2014/06) Effect of dehydroepiandrosterone administration in patients with poor ovarian response according to the Bologna criteria.

(2014/06) Role of dehydroepiandrosterone in improving oocyte and embryo quality in IVF cycles.

(2014/02) Does dehydroepiandrosterone supplementation really affect IVF-ICSI outcome in women with poor ovarian reserve?

(2014/01) DHEA pre-treated patients, poor responders to a first IVF (ICSI) cycle: clinical results.

(2013/11) A prospective study on role of dehydroepiandrosterone (DHEA) on improving the ovarian reserve markers in infertile patients with poor ovarian reserve.

(2013/10) DHEA supplementation positively affects spontaneous pregnancies in women with diminished ovarian function.

(2013/07) Dehydroepiandrosterone supplementation improves predictive markers for diminished ovarian reserve: serum AMH, inhibin B and antral follicle count.

(2013/05) DHEA supplementation may improve IVF outcome in poor responders: a proposed mechanism.

(2013/01) Starting and resulting testosterone levels after androgen supplementation determine at all ages in vitro fertilization(IVF) pregnancy rates in women with diminished ovarian reserve (DOR).

(2012/09) DHEA supplementation improves follicular microenviroment in poor responder patients.

(2010/10) Addition of dehydroepiandrosterone (DHEA) for poor-responder patients before and during IVF treatment improves the pregnancy rate: a randomized prospective study.

(2010/11) Dehydroepiandrosterone (DHEA) reduces embryo aneuploidy: direct evidence from preimplantation genetic screening (PGS).

(2010/10) Addition of dehydroepiandrosterone (DHEA) for poor-responder patients before and during IVF treatment improves the pregnancy rate: a randomized prospective study.

Folate/Folic Acid

(2019/01) Comparison of metformin plus myoinositol vs metformin alone in PCOS women undergoing ovulation induction cycles: randomized controlled trial.

(2018/12) Inositol for subfertile women with polycystic ovary syndrome.

(2018/10) Myo-inositol supplementation reduces the amount of gonadotropins and length of ovarian stimulation in women undergoing IVF: a systematic review and meta-analysis of randomized controlled trials.

(2018/02) Inositol treatment of anovulation in women with polycystic ovary syndrome: a meta-analysis of randomised trials.

(2017/12) Inositol supplement improves clinical pregnancy rate in infertile women undergoing ovulation induction for ICSI or IVF-ET.

(10/2016) Inositol Treatment and ART Outcomes in Women with PCOS.

(08/2016) Prospective Randomized Study on the Influence of Myoinositol in PCOS Women Undergoing IVF in the Improvement of Oocyte Quality, Fertilization Rate, and Embryo Quality

(08/2015) Inositol versus Metformin administration in polycystic ovary syndrome patients: a case–control study

(06/2015) Myo-inositol therapy for poor-responders during IVF: a prospective controlled observational trial

(02/2015) Ovulation induction with myo-inositol alone and in combination with clomiphene citrate in polycystic ovarian syndrome patients with insulin resistance

(12/2013) The combined therapy myo-inositol plus D-chiro-inositol, rather than D-chiro-inositol, is able to improve IVF outcomes: results from a randomized controlled trial

(04/2013) Endocrine and clinical effects of myo-inositol administration in polycystic ovary syndrome. A randomized study.

(07/2012) Pretreatment with myo-inositol in non polycystic ovary syndrome patients undergoing multiple follicular stimulation for IVF: a pilot study.

(05/2011) Effects of myo-inositol supplementation on oocyte's quality in PCOS patients: a double-blind trial.

(04/2011) Myo-inositol rather than D-chiro-inositol is able to improve oocyte quality in intracytoplasmic sperm injection cycles. A prospective, controlled, randomized trial.

(04/2010) Insulin sensitiser agents alone and in co-treatment with r-FSH for ovulation induction in PCOS women.

(05/2009) Myo-inositol may improve oocyte quality in intracytoplasmic sperm injection cycles. A prospective, controlled, randomized trial.

(09/2007) Randomized, double blind placebo-controlled trial: effects of myo-inositol on ovarian function and metabolic factors in women with PCOS.


(2017/12) The impact of melatonin on the sleep patterns of women undergoing IVF: a double blind RCT.

(2017/04) Melatonin levels in follicular fluid as markers for IVF outcomes and predicting ovarian reserve.

(2016/01) Effect of myo-inositol and melatonin versus myo-inositol, in a randomized controlled trial, for improving in vitro fertilization of patients with polycystic ovarian syndrome.

(2014/10) Melatonin: shedding light on infertility? - a review of the recent literature.

(2014/05) Oral melatonin supplementation improves oocyte and embryo quality in women undergoing in vitro fertilization-embryo transfer.

(2014/01) Melatonin supplementation during controlled ovarian stimulation for women undergoing assisted reproductive technology: systematic review and meta-analysis of randomized controlled trials.

(2012/02) The efficacy of melatonin administration on oocyte quality.

(2011/11) Effect of a supplementation with myo-inositol plus melatonin on oocyte quality in women who failed to conceive in previous in vitro fertilization cycles for poor oocyte quality: a prospective, longitudinal, cohort study.

(2011/09) Melatonin improves the oocyte and the embryo in IVF patients with sleep disturbances, but does not improve the sleeping problems.

(2010/06) Effect of the treatment with myo-inositol plus folic acid plus melatonin in comparison with a treatment with myo-inositol plus folic acid on oocyte quality and pregnancy outcome in IVF cycles. A prospective, clinical trial.

(2008/04) Oxidative stress impairs oocyte quality and melatonin protects oocytes from free radical damage and improves fertilization rate.

Omega-3 Fatty Acids
Vitamin D


Male Fertility

Coenzyme Q10
Folate/Folic Acid
Omega-3 Fatty Acids
Vitamin C
Vitamin D
Vitamin E






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